Cyclobenzaprine: Generic, Uses, Side Effects, Dosages, Interactions & Warnings
Cyclobenzaprine is the most heavily studied and has been shown to be effective for various musculoskeletal conditions. The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited.
Some medicines can interact with cyclobenzaprine and cause a serious condition called serotonin syndrome. Ask your doctor before making any changes in how or when you take your medications. The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients. One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, and relief from starting backache.
Flexeril should also be used with caution in individuals with liver problems. If you have liver problems, your doctor may try to keep you on a lower dose. Don’t take this medicine for longer than three weeks without talking to your doctor. The immediate-release tablets last for about four to six hours, while the extended-release tablets last around 24 hours. UseCyclobenzaprine (Flexeril) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Common Cyclobenzaprine Side Effects
Elderly patients seem to tolerate cyclobenzaprine less and may develop hallucinations as well as significant anticholinergic side effects, such as sedation. The use of significant lower dosing schedules in elderly patients may be prudent. The most common adverse reactions to cyclobenzaprine are somnolence, dry mucous membranes, dizziness, and confusion. Less commonly, tachycardia, dysarthria, disorientation, and hallucinations have been reported .
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These two dangerous consequences of Flexeril abuse are exacerbated by the fact that mixing drugs with cyclobenzaprine can make Flexeril addictive and deadly on a whole new level. Taking Flexeril with MAOs puts a person at high risk of a dangerous medical condition. It can occur when Tetracyclic Compounds and MAOIs both raise the level of serotonin too high in the body. It can cause changes in blood pressure, body temperature and lead to a change in behavior. If a person has an overactive thyroid, heart issues or problems with the liver, Flexeril can be risky and should not be taken. Whether cyclobenzaprine is superior to other drugs for the management of acute myofascial strain is unclear and it usually adds more side effects with little therapeutic gain (Turturro et al 2003).
You have never felt such a feeling of relaxation in your entire life. I can easily see how someone might become addicted to it though. Side effects of tricyclic antidepressants include drowsiness, blurred vision, and drop in blood pressure when standing up after sitting (20). Some patients taking SNRIs report nausea, dizziness, and dizziness (21). Both SSRIs and SNRIS may be linked to serotonin syndrome (23). Skeletal muscle relaxants are a unique and interesting drug class.
Robaxin needs to be taken three to four times a day to provide relief from muscle pain and muscle spasms. Cyclobenzaprine is used to help relax certain muscles in your body. It helps relieve pain, stiffness, and discomfort caused by strains, sprains, or injuries to your muscles. However, this medicine does not take the place of rest, exercise or physical therapy, or other treatment that your doctor may recommend for your medical problem.
Veterinarians suggest short-term treatments with Flexeril for dogs and cats with acute muscle spasms. However, the dosage strength differs for humans and dogs, and dogs are at dosages of flexeril risk for addiction. The drug Cyclobenzaprine, sold under the brand Flexeril, is structurally very similar to a class of Antidepressants called Tricyclic Antidepressants.
- Zanaflex, or tizanidine, is a muscle relaxant used to treat muscle spasticity due to multiple sclerosis and spinal cord injury.
- It isn’t known exactly how this drug works to relax your muscles.
- Cyclobenzaprine is used short-term to treat muscle spasms.
- Call your doctor or local poison control center immediately if you have an allergic reaction.
Flexeril is a medication belonging to a class of skeletal muscle relaxants used to treat muscle spasms. These spasms may be induced by significant injuries of the musculoskeletal system or even due to usual physiological activities. This muscle relaxant works by blocking the pain signals and relieves the discomfort caused by muscle spasms. It is available in the form of tablets and extended-release capsules.
Evidence of Effectiveness
Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome). Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems. For most patients, the recommended dose of FLEXERIL is 5 mg three times a day.